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dc.contributor.authorTort, Fernando L.
dc.contributor.authorCastells, Matías
dc.contributor.authorCristina, Juan
dc.date.accessioned2020-05-01T20:41:07Z
dc.date.available2020-05-01T20:41:07Z
dc.date.issued2020-07-02
dc.identifier.urihttps://doi.org/10.1016/j.virusres.2020.197976en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/1270
dc.description.abstractAn outbreak of atypical pneumonia caused by a novel Betacoronavirus (βCoV), named SARS-CoV-2 has been declared a public health emergency of international concern by the World Health Organization. In order to gain insight into the emergence, evolution and adaptation of SARS-CoV-2 viruses, a comprehensive analysis of genome composition and codon usage of βCoV circulating in China was performed. A biased nucleotide composition was found for SARS-CoV-2 genome. This bias in genomic composition is reflected in its codon and amino acid usage patterns. The overall codon usage in SARS-CoV-2 is similar among themselves and slightly biased. Most of the highly frequent codons are A- and U-ending, which strongly suggests that mutational bias is the main force shaping codon usage in this virus. Significant differences in relative synonymous codon usage frequencies among SARS-CoV-2 and human cells were found. These differences are due to codon usage preferences.en_US
dc.languageEnglishen_US
dc.subjectCOVID-19en_US
dc.subjectCoronavirusen_US
dc.subjectInfectious Diseasesen_US
dc.subjectCodonen_US
dc.subjectSARS-CoV-2en_US
dc.titleA comprehensive analysis of genome composition and codon usage patterns of emerging coronavirusesen_US
eihealth.countryOthersen_US
eihealth.categoryVirus: natural history, transmission and diagnosticsen_US
eihealth.typePublished Articleen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.relation.ispartofjournalVirus Researchen_US


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