dc.contributor.author | Tort, Fernando L. | |
dc.contributor.author | Castells, Matías | |
dc.contributor.author | Cristina, Juan | |
dc.date.accessioned | 2020-05-01T20:41:07Z | |
dc.date.available | 2020-05-01T20:41:07Z | |
dc.date.issued | 2020-07-02 | |
dc.identifier.uri | https://doi.org/10.1016/j.virusres.2020.197976 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1270 | |
dc.description.abstract | An outbreak of atypical pneumonia caused by a novel Betacoronavirus (βCoV), named SARS-CoV-2 has been declared a public health emergency of international concern by the World Health Organization. In order to gain insight into the emergence, evolution and adaptation of SARS-CoV-2 viruses, a comprehensive analysis of genome composition and codon usage of βCoV circulating in China was performed. A biased nucleotide composition was found for SARS-CoV-2 genome. This bias in genomic composition is reflected in its codon and amino acid usage patterns. The overall codon usage in SARS-CoV-2 is similar among themselves and slightly biased. Most of the highly frequent codons are A- and U-ending, which strongly suggests that mutational bias is the main force shaping codon usage in this virus. Significant differences in relative synonymous codon usage frequencies among SARS-CoV-2 and human cells were found. These differences are due to codon usage preferences. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Codon | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | A comprehensive analysis of genome composition and codon usage patterns of emerging coronaviruses | en_US |
eihealth.country | Others | en_US |
eihealth.category | Virus: natural history, transmission and diagnostics | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Virus Research | en_US |