The value of urine biochemical parameters in the prediction of the severity of coronavirus disease 2019

Abstract

Coronavirus is an RNA virus with an enveloped positive-sense RNA that can grow in epithelial cells and mainly cause respiratory infection, including severe acute respiratory syndrome (SARS), and acute exacerbation of chronic bronchitis (AECB) in humans, and the SARS-CoV epidemic caused great social panic in 2003. A novel coronavirus, designated SARS-CoV-2, was first discovered in 2019 in Wuhan, China. The virus is a novel human pathogen and has the ability to infect multiple host species. The disease caused by SARS-CoV-2 was named coronavirus disease 2019 (COVID-19) by the WHO, and this term mainly refers to the ongoing outbreak of SARS-CoV-2-infected pneumonia in China. Patients with severe cases of COVID-19 show dyspnea accompanied by hypoxemia, and some of them have acute respiratory distress syndrome (ARDS), septic shock and multiple organ failure. The abnormal hematology results of patients with COVID-19 include lower lymphocytes, higher lactate dehydrogenase (LDH), higher creatine kinase (CK) and its isoenzymes and higher C-reactive protein (CRP) and inflammatory factors. Urine dry chemical tests have the characteristics of being quick, convenient and economical, and the biochemical parameters of urine can be used for the auxiliary diagnosis of urinary tract infections (UTIs), the diagnosis of kidney diseases and the monitoring of treatment effects. Until now, there have been no reports about the correlation between urine biochemical parameters and COVID-19; therefore, the aim of this study was to explore the value of urine biochemical parameters in the prediction of the severity of COVID-19.