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dc.date.accessioned2020-04-21T15:35:34Z
dc.date.available2020-04-21T15:35:34Z
dc.date.issued2020-04-12
dc.identifier.urihttps://www.who.int/news-room/commentaries/detail/bacille-calmette-guérin-(bcg)-vaccination-and-covid-19en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/1136
dc.description.abstractSummary: There is no evidence that the Bacille Calmette-Guérin vaccine (BCG) protects people against infection with COVID-19 virus. Two clinical trials addressing this question are underway, and WHO will evaluate the evidence when it is available. In the absence of evidence, WHO does not recommend BCG vaccination for the prevention of COVID-19. WHO continues to recommend neonatal BCG vaccination in countries or settings with a high incidence of tuberculosis. There is experimental evidence from both animal and human studies that the BCG vaccine has non-specific effects on the immune system. These effects have not been well characterized and their clinical relevance is unknown. On 11 April 2020, WHO updated its ongoing evidence review of the major scientific databases and clinical trial repositories, using English, French and Chinese search terms for COVID-19, coronavirus, SARS-CoV-2 and BCG. The review yielded three preprints (manuscripts posted online before peer-review), in which the authors compared the incidence of COVID-19 cases in countries where the BCG vaccine is used with countries where it is not used and observed that countries that routinely used the vaccine in neonates had less reported cases of COVID-19 to date. Such ecological studies are prone to significant bias from many confounders, including differences in national demographics and disease burden, testing rates for COVID-19 virus infections, and the stage of the pandemic in each country...en_US
dc.languageEnglishen_US
dc.subjectCOVID-19en_US
dc.subjectCoronavirusen_US
dc.subjectInfectious Diseasesen_US
dc.subjectMycobacterium bovisen_US
dc.subjectBacille Calmette-Guérin vaccine (BCG)en_US
dc.titleBacille Calmette-Guérin (BCG) vaccination and COVID-19. Scientific Brief, 12 April 2020en_US
eihealth.countryGlobal (WHO/OMS)en_US
eihealth.categoryCandidate vaccines RDen_US
eihealth.typeWHO / PAHO Guidanceen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.contributor.corporatenameWorld Health Organizationen_US


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