Potential use of ozone in SARS-CoV-2 / COVID-19

Abstract

Systemic ozone therapy can be “potentially” useful in SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown to be highly effective in research studies. The mechanism of action will be by 1) The induction of adaptation to oxidative stress, hence a re-equilibration of the cellular redox state. 2) The induction of IFN-gamma and proinflammatory cytokines. 3) The increase of blood flow and tissue oxygenation to vital organs. 4) It has the potential actions to act as an auto-vaccine when administered in form of minor autohemotherapy. The recommended routes of administration are: Major Autohemotherapy (MAH), Ozonized Saline Solution (O3SS), Extracorporeal Blood Oxygenation-Ozonation (EBOO), and a variant of the Minor Autohemotherapy (MiAH). Clinical protocol should be adhered to with the standard doses and procedures as defined in the Madrid Declaration of Ozone Therapy. It is a complementary therapy because while the infected patient will continue to be treated with allopathic medicine, at the same time the patient will receive the treatment that this paper is proposing. At least three clinical trials using major autohemotherapy are currently being undertaken in China and more clinical trials and data are needed to confirm the efficacy of ozone therapy as a complementary therapy in COVID-19 diseases.