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dc.contributor.authorQin, Chuan et al.
dc.date.accessioned2020-04-20T17:56:43Z
dc.date.available2020-04-20T17:56:43Z
dc.date.issued2020-03-12
dc.identifier.urihttps://academic.oup.com/cid/article/doi/10.1093/cid/ciaa248/5803306en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/1114
dc.description.abstract[Conclusions] Of the 452 patients with COVID-19 recruited, 286 were diagnosed as severe infection. The median age was 58 years and 235 were male. The most common symptoms were fever, shortness of breath, expectoration, fatigue, dry cough and myalgia. Severe cases tend to have lower lymphocytes counts, higher leukocytes counts and neutrophil-lymphocyte-ratio (NLR), as well as lower percentages of monocytes, eosinophils, and basophils. Most of severe cases demonstrated elevated levels of infection-related biomarkers and inflammatory cytokines. The number of T cells significantly decreased, and more hampered in severe cases. Both helper T cells and suppressor T cells in patients with COVID-19 were below normal levels, and lower level of helper T cells in severe group. The percentage of naïve helper T cells increased and memory helper T cells decreased in severe cases. Patients with COVID-19 also have lower level of regulatory T cells, and more obviously damaged in severe cases.en_US
dc.languageEnglishen_US
dc.subjectCOVID-19en_US
dc.subjectChinaen_US
dc.subjectLymphocytesen_US
dc.subjectT-Lymphocytes, Helper-Induceren_US
dc.titleDysregulation of immune response in patients with COVID-19 in Wuhan, Chinaen_US
eihealth.countryOthersen_US
eihealth.categoryCandidate therapeutics RDen_US
eihealth.typePublished Articleen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.relation.ispartofjournalClinical Infectious Diseasesen_US


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