Show simple item record

dc.contributor.authorTerpos, Evangelos et al.
dc.date.accessioned2020-04-18T01:36:56Z
dc.date.available2020-04-18T01:36:56Z
dc.date.issued2020-04-13
dc.identifier.urihttps://doi.org/10.1002/ajh.25829en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12663/1076
dc.description.abstractCOVID‐19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Lymphopenia may be considered as a cardinal laboratory finding, with prognostic potential. Neutrophil/lymphocyte ratio and peak platelet/lymphocyte ratio may also have prognostic value in determining severe cases. During the disease course, longitudinal evaluation of lymphocyte count dynamics and inflammatory indices, including LDH, CRP and IL‐6 may help to identify cases with dismal prognosis and prompt intervention in order to improve outcomes. Biomarkers, such high serum procalcitonin and ferritin have also emerged as poor prognostic factors. Furthermore, blood hypercoagulability is common among hospitalized COVID‐19 patients. Elevated D‐Dimer levels are consistently reported, whereas their gradual increase during disease course is particularly associated with disease worsening. Other coagulation abnormalities such as PT and aPTT prolongation, fibrin degradation products increase, with severe thrombocytopenia lead to life‐threatening Disseminated intravascular coagulation (DIC) which necessitates continuous vigilance and prompt intervention. COVID‐19 infected patients whatever hospitalized or ambulatory are at high risk for VTE and an early and prolonged pharmacological thromboprophylaxis with low molecular weight heparin is highly recommended. Last but not least, the need for assuring blood donations during the pandemic is also highlighted.en_US
dc.languageEnglishen_US
dc.subjectCOVID-19en_US
dc.subjectCoronavirusen_US
dc.subjectInfectious Diseasesen_US
dc.subjectHematologyen_US
dc.subjectHematopoietic Systemen_US
dc.subjectHemostasisen_US
dc.subjectLymphopeniaen_US
dc.subjectNeutrophilsen_US
dc.subjectLymphocytesen_US
dc.titleHematological findings and complications of COVID‐19en_US
eihealth.countryOthersen_US
eihealth.categoryClinical characterization and managementen_US
eihealth.typeOther publicationsen_US
eihealth.maincategorySave Lives / Salvar Vidasen_US
dc.relation.ispartofjournalAmerican Journal of Hematologyen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record