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The digital repository system captures, stores, indexes, preserves, and distributes digital research material.2024-03-18T23:56:21ZRepelente corporal baseado no Líquido da Casca da castanha de caju - LCC com ação repelente contra o mosquito Aedes aegypti transmissor da Dengue, Febre Chikungunya e Zika
https://hdl.handle.net/20.500.12663/3398
Repelente corporal baseado no Líquido da Casca da castanha de caju - LCC com ação repelente contra o mosquito Aedes aegypti transmissor da Dengue, Febre Chikungunya e Zika
Mazzetto, Selma Elaine
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2016-01-01T00:00:00ZNucleoside inhibitors of Zika virus
https://hdl.handle.net/20.500.12663/3397
Nucleoside inhibitors of Zika virus
Eyer, Luděk; Nencka, Radim; Huvarová, Ivana; et al.; et al.
There is growing evidence that Zika virus (ZIKV) can cause devastating infant brain defects and other neurological disorders in humans. However, no specific antiviral therapy is available at present. We tested a series of 2′-C- or 2′-O-methyl–substituted nucleosides, 2′-C-fluoro-2′-C-methyl–substituted nucleosides, 3′-O-methyl–substituted nucleosides, 3′-deoxynucleosides, derivatives with 4′-C-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit ZIKV replication in cell culture. Antiviral activity was identified when 2′-C–methylated nucleosides were tested, suggesting that these compounds might represent promising lead candidates for further development of specific antivirals against ZIKV.
2016-01-01T00:00:00ZZika virus. II. Pathogenicity and physical properties
https://hdl.handle.net/20.500.12663/3396
Zika virus. II. Pathogenicity and physical properties
Dick, G. W. A.
(1) A description is given of the adaptation to mice of two strains of Zika virus. Zika is the name of a forest area near Entebbe, Uganda, where both strains of virus were isolated. One of the strains was isolated from a pyrexial rhesus monkey which was being employed as a yellow fever sentinel and the other was obtained from a batch of A. africanus.
(2) The signs of infection in mice are described. While mice of all ages tested are susceptible to intracerebral inoculations with Zika mouse brain virus, mice of 2 weeks of age and over can rarely be infected by the intraperitoneal route. Mice younger than 2 weeks are highly susceptible to intraperitoneal inoculation of the virus.
(3) Zika virus is highly neurotropic in mice and no virus has been recovered from tissues other than the brains of infected mice.
(4) Cotton-rats, guineapigs and rabbits show no clinical signs of infection after intracerebral inoculation of late passage mouse brain virus.
(5) Monkeys develop an inapparent infection after subcutaneous inoculation with mouse brain virus. After intracerebral inoculation one of five monkeys showed a mild pyrexia, the others showed no signs of infection. Viraemia during the first week after inoculation has been found in all monkeys tested and antibody has been demonstrated by the 14th day after inoculation.
(6) Of 99 human sera tested, 6 (6.1 per cent.)-have neutralized more than 100 LD50 of virus. Antibody has also been found in the serum of one of 15 wild monkeys tested.
(7) The size of Zika virus is estimated to eb in the region of 30 to 45 mμ in diameter. The virus may be preserved up to 6 months in 50 per cent. glycerol and up to 30 months after drying. It is susceptible to anaesthetic ether and the thermal death point is 58°C. for 30 minutes.
(8) Neuronal degeneration, cellular infiltration and areas of softening are present in infected mouse brains. Cowdry type A inclusion bodies have been found, particularly in the brains of young mice showing extensive lesions.
1952-01-01T00:00:00ZZika virus. I. Isolations and serological specifi city
https://hdl.handle.net/20.500.12663/3395
Zika virus. I. Isolations and serological specifi city
Dick, G. W. A.; Kitchen, S. F.; Haddow, A. J.
(1) The isolation of what is believed to be a hitherto unrecorded virus is described. The first isolation was made in April 1947 from the serum of a pyrexial rhesus monkey caged in the canopy of Zika Forest. The second isolation was made from a lot of A. africanus taken in January, 1948, in the same forest. The virus has been called Zika virus after the locality from where the isolations were made.
(2) Cross neutralization tests indicate that Zika virus is not related to yellow fever, Hawaii dengue nor to the FA and GD VII strains of Theiler's mouse encephalomyelitis virus. Neutralization tests with Zika virus and the antisera of some other viruses which are neurotropic in mice gave no evidence of any identity of these with Zika virus.
1952-01-01T00:00:00Z