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Breakthrough: Chloroquine Phosphate Has Shown Apparent Efficacy in Treatment of COVID-19 Associated Pneumonia in Clinical Studies
(2020-02-29)The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is ... -
Lianhuaqingwen Exerts Anti-Viral and Anti-Inflammatory Activity Against Novel Coronavirus (SARS-CoV-2)
(2020-03-20)Purpose: Lianhuaqingwen (LH) as traditional Chinese medicine (TCM) formula has been used to treat influenza and exerted broad-spectrum antiviral effects on a series of influenza viruses and immune regulatory effects [1]. ... -
Investigational COVID-19 Convalescent Plasma - Emergency INDs
(2020-03-24)The Food and Drug Administration (FDA or Agency) plays a critical role in protecting the United States from public health threats including the Coronavirus Disease 2019 (COVID-19) pandemic. FDA is committed to doing ... -
Anti-hypertensive Angiotensin II receptor blockers associated to mitigation of disease severity in elderly COVID-19 patients
(2020-03-27)Background: The novel coronavirus (CoV) severe acute respiratory syndrome (SARS)-CoV-2 outbreak started at the end of 2019 in Wuhan, China, and spread over 100 countries. SARS-CoV-2 uses the membrane protein Angiotensin I ... -
A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19
(2020-03-10)Purpose: COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting ... -
Chloroquine and hydroxychloroquine: Current evidence for their effectiveness in treating COVID-19
(2020-03-25)Verdict: Several in vitro studies report antiviral activity of chloroquine and hydroxychloroquine against SARS-CoV-2. In vivo data, although promising, is currently limited to one study with considerable limitations. On ... -
Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis
(2020-03-30)A growing body of literature on the 2019 novel coronavirus (SARS-CoV-2) is becoming available, but a synthesis of available data has not been conducted. We performed a scoping review of currently available clinical, ... -
A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
(2020-03-18)[Methods] We conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao2 ) ... -
Viral RNA load as determined by cell culture as a management tool for discharge of SARS-CoV-2 patients from infectious disease wards: draft
(2020-03)In a preliminary clinical study we observed that the combination of hydroxychloroquine and azithromycin was effective active against SARS-CoV-2 by shortening the duration of viral load in Covid-19 patients. It is of paramount ... -
In vitro testing of Hydroxychloroquine and Azithromycin on SARS-CoV-2 shows synergistic effect
(2020-03)Human coronaviruses SARS-CoV-2 appeared at the end of 2019 and led to a pandemic with high morbidity and mortality. As there are currently no effective drugs targeting this virus, drug repurposing represents a short-term ...