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Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus
(2020-04-01)Motivation: Since December 2019, the newly identified coronavirus SARS-CoV-2 has caused a massive health crisis worldwide and resulted in over 70,000 COVID-19 infections so far. Clinical drugs targeting SARS-CoV-2 are ... -
Estimates of the severity of coronavirus disease 2019: a model-based analysis
(2020-03-30)Background: In the face of rapidly changing data, a range of case fatality ratio estimates for coronavirus disease 2019 (COVID-19) have been produced that differ substantially in magnitude. We aimed to provide robust ... -
The use of google trends to investigate the loss of smell related searches during COVID‐19 outbreak
(2020-04-11)[Abstract]. Background: Initial reports describing COVID‐19 were dominated by the presence of cough, breathlessness, and fever, anecdotal reports suggested anosmia may also be a manifestation. We sought to use Google Trends ... -
Mathematical model of infection kinetics and its analysis for COVID-19, SARS and MERS
(2020-04-08)The purpose of this paper is to reveal the spread rules of the three pneumonia: COVID-19, SARS and MERS. We compare the new spread characteristics of COVID-19 with those of SARS and MERS. By considering the growth rate and ... -
Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China
(2020-03-19)As of 29 February 2020 there were 79,394 confirmed cases and 2,838 deaths from COVID-19 in mainland China. Of these, 48,557 cases and 2,169 deaths occurred in the epicenter, Wuhan. A key public health priority during the ... -
Association of chemosensory dysfunction and Covid‐19 in patients presenting with influenza‐like symptoms
(2020-04-12)[Abstract]. Background: Rapid spread of the SARS‐CoV‐2 virus and concern for viral transmission by ambulatory patients with minimal to no symptoms underline the importance of identifying early or subclinical symptoms of ... -
Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis
(2020-03-15)Objective: To better inform efforts to treat and control the current outbreak with a comprehensive char- acterization of COVID-19. Methods: We searched PubMed, EMBASE, Web of Science, and CNKI (Chinese Database) for studies ... -
COVID-19 in Children in the United States: Intensive Care Admissions, Estimated Total Infected, and Projected Numbers of Severe Pediatric Cases in 2020
(2020-04-16)[Abstract]. Importance: A surge in severe cases of COVID-19 (coronavirus disease 2019) in children would present unique challenges for hospitals and public health preparedness efforts in the United States. Objective: To ... -
Community quarantine strategy against coronavirus disease 2019 in Anhui: an evaluation based on trauma center patients
(2020-04-06)[Abstract]. Objective: The objective of our study was to introduce community quarantine strategy against coronavirus disease 2019(COVID-19) in Anhui and evaluate the effectiveness of community quarantine based on trauma ... -
Vertical Transmission of Coronavirus Disease 19 (COVID-19) from Infected Pregnant Mothers to Neonates: A Review
(2020-04-02)Background: Since early December 2019, the Coronavirus Disease 19 (COVID-19) infection has been prevalent in China and eventually spread to other countries. There are a few published cases of COVID-19 occurring during ...