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Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review
(2020-02-26)Rapid diagnostics, vaccines and therapeutics are important interventions for the management of the 2019 novel coronavirus (2019-nCoV) outbreak. It is timely to systematically review the potential of these interventions, ... -
What makes health systems resilient against infectious disease outbreaks and natural hazards? Results from a scoping review.
(2019-10-19)BACKGROUND:The 2014-2016 Ebola outbreak was a wake-up call regarding the critical importance of resilient health systems. Fragile health systems can become overwhelmed during public health crises, further exacerbating the ... -
Non-severe vs severe symptomatic COVID-19: 104 cases from the outbreak on the cruise ship “Diamond Princess” in Japan
(2020-03-20)Background: The ongoing outbreak of 2019 novel coronavirus disease (COVID-19) is a global threat. Clarifying its clinical features such as risk factors for disease progression is a pressing issue. We analyzed the difference ... -
Potential interventions for novel coronavirus in China: A systematic review
(2020-02-04)An outbreak of a novel coronavirus (COVID‐19 or 2019‐CoV) infection has posed significant threats to international health and the economy. In the absence of treatment for this virus, there is an urgent need to find alternative ... -
COVID 19 Public Health Emergency of International Concern (PHEIC). Global research and innovation forum: towards a research roadmap
(2020-02-12)Over the first 6 weeks of the new decade, the novel coronavirus, known as COVID-19, has spread from the People’s Republic of China to 20 other countries. On 30 January 2020 following the recommendations of the Emergency ... -
Additional steroid treatment for patients with influenza who are critically ill: Uncertain whether beneficial or harmful
(2020-03-16)What is this? Corticosteroids are widely used for people with severe influenza, but there is uncertainty about their potential benefits or harms. Corticosteroids have shown evidence of benefit in sepsis and related conditions, ... -
Colloids and crystalloids may have similar effects on mortality when used for fluid replacement in critically ill patients
(2020-03-16)What is this? Some patients with COVID-19 will become critically ill and may need additional fluids to prevent kidney failure. Fluid replacement options include colloids or crystalloids. Colloids are cheap and easy to use ... -
Enteral, parenteral nutrition and their combination for adults in the intensive care unit
(2020-03-17)What is this? Some patients with COVID-19 will become critically ill and need treatment in an intensive care unit (ICU). This may interrupt their feeding routines and reduce appetite or increase nausea and vomiting, leading ... -
Chinese herbs combined with Western medicine in the treatment of severe acute respiratory syndrome (SARS)
(2020-03-19)What is this? The first cases of severe acute respiratory syndrome (SARS) were reported in December 2002. This is an acute respiratory disease caused by a coronavirus and integrated Chinese and Western medicines may have ... -
Buffered solutions did not reduce mortality compared to 0.9% saline for resuscitation in critically ill adults and children
(2020-03-22)What is this? Some patients with COVID-19 will become critically ill and need intravenous fluids. Saline 0.9% is the most commonly used crystalloid solutions for critically ill patients, but buffered solutions are also ...