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Prevención y control de infecciones en los centros de atención de larga estancia en el contexto de la COVID-19: orientaciones provisionales, 21 marzo de 2020
(2020-03-20)Antecedentes El 30 de enero de 2020, la OMS declaró que el brote de COVID-19 constituía una emergencia de salud pública de importancia internacional. Inicialmente, la mayoría de los casos se notificaron en China y en ... -
Recomendações aos Estados-Membros sobre melhorias nas práticas de higienização das mãos para ajudar a prevenir a transmissão do vírus causador da doença COVID-19. Orientação provisória, 1 de abril de 2020
(2020-04-30)Introdução: As evidências atuais indicam que o vírus causador da doença COVID-19 é transmitido através de gotículas respiratórias ou por contato. A transmissão por contato ocorre quando as mãos contaminadas tocam a mucosa ... -
Convalescent plasma treatment of severe COVID-19: A matched control study
(2020-05-22)Background Since December 2019, Coronavirus Disease 2019 (COVID-19) has become a global pandemic, causing mass morbidity and mortality. Prior studies in other respiratory infections suggest that convalescent plasma transfusion ... -
Sarilumab use in severe SARS-CoV-2 pneumonia
(2020-05-18)Interleukin-6 signal blockade has shown preliminary beneficial effects in treating aberrant host inflammatory response against SARS-CoV-2 leading to severe respiratory distress. Objective: to describe the effect of off-label ... -
SARS-CoV-2 seroconversion in health care workers
(2020-05-19)Background The correlates of protection against SARS-CoV-2 and their longevity remain unclear. Studies in severely ill individuals have identified robust cellular and humoral immune responses against the virus. Asymptomatic ... -
Serologic responses to SARS-CoV-2 infection among hospital staff with mild disease in eastern France
(2020-05-22)Background: The serologic response of individuals with mild forms of SARS-CoV-2 infection is poorly characterized. Methods: Hospital staff who had recovered from mild forms of PCR-confirmed SARS-CoV-2 infection were tested ... -
Off-Label Real World Experience Using Tocilizumab for Patients Hospitalized with COVID-19 Disease in a Regional Community Health System: A Case-Control Study
(2020-05-19)Objective: To determine if Tocilizumab treatment in patients hospitalized with laboratory confirmed SARS-CoV-2 infection and subsequent COVID-19 disease provides short-term survival benefit. Design: Case-control, observational ... -
Susceptibility to and transmission of COVID-19 amongst children and adolescents compared with adults: a systematic review and meta-analysis
(2020-05-24)Background The degree to which children and young people are infected by and transmit the SARS-CoV-2 virus is unclear. Clinical series and testing cohorts based upon screening of symptomatic cases provide biased estimates ... -
High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design
(2020-05-22)Little is known about the quality of polyclonal antibody responses in COVID-19 patients, and how it correlates with disease severity or patients' prior exposure to other pathogens. The whole polyclonal antibody repertoire ...