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Increased PCR screening capacity using a multi-replicate pooling scheme
(2020-04-22)Effective public health response to viral outbreaks such as SARS-CoV-2 is often informed by real-time PCR screening of large populations. Pooling samples can increase screening capacity. However, when a traditional pool ... -
Increased PCR screening capacity using a multi-replicate pooling scheme
(2020-04-22)Effective public health response to viral outbreaks such as SARS-CoV-2 is often informed by real-time PCR screening of large populations. Pooling samples can increase screening capacity. However, when a traditional pool ... -
Innovative screening tests for COVID-19 in South Korea
(2020-04-13)Recently, the number of Corona Virus Disease 2019 (COVID-19) cases has increased remarkably in South Korea, so the triage clinics and emergency departments (ED) are expected to be overcrowded with patients with presumed ... -
Interim laboratory biosafety guidelines for the handling and transport of samples associated with the novel coronavirus 2019 (2019-nCoV), 28 January 2020
(2020-01-28)In January 2020, the etiologic agent responsible for a cluster of severe pneumonia cases in Wuhan, China, was identified as a novel beta-coronavirus (2019-nCoV), distinct than SARS-CoV and MERS-CoV (1) (2) (3). The complete ... -
Laboratory biosafety guidance related to coronavirus disease 2019 (COVID-19) Interim guidance 12 February 2020
The purpose of this document is to provide interim guidance on laboratory biosafety related to the testing of clinical specimens of patients that meet the case definition of the novel pathogen identified in Wuhan, China, ... -
Laboratory Guidelines for Detection and Diagnosis of the Novel Coronavirus (2019-nCoV) Infection, February 01, 2020
(2020-02-01)Coronaviruses are a group of highly diverse RNA virus in the Coronaviridae family that are divided in 4 genera: alpha, beta, gamma and delta that cause disease varying from mild to severe in human and animals. There are ... -
Laboratory preparedness for SARS-CoV-2 testing in India: Harnessing a network of Virus Research & Diagnostic Laboratories
(2020)Background & objectives: An outbreak of respiratory illness of unknown aetiology was reported from Hubei province of Wuhan, People's Republic of China, in December 2019. The outbreak was attributed to a novel coronavirus ... -
Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases, Interim guidance, 2 March 2020
Overview. The purpose of this document is to provide interim guidance to laboratories and stakeholders involved in laboratory testing of patients who meet the definition of suspected case of pneumonia associated with a ... -
Large-scale implementation of pooled RNA-extraction and RT-PCR for SARS-CoV-2 detection
(2020-05-07)Testing for active SARS-CoV-2 infection is a fundamental tool in the public health measures taken to control the COVID-19 pandemic. Due to the overwhelming use of SARS-CoV-2 RT-PCR tests worldwide, availability of test ... -
List of Priority Medical Devices in the context of COVID-19 (provisional recommendations, 06 April 2020) 3rd Version
(2020-04-06)Objective of the document: The list of priority medical devices in the context of COVID-19 provides technical descriptions and specifications for the management of patients with suspected and/or confirmed COVID-19 infection ... -
Male predisposition to severe COVID-19: Review of evidence and potential therapeutic prospects
(2020-09-18)The severe form of COVID-19 has significant sex disparities, with high fatalities commonly reported among males than females. The incidence of COVID-19 has also been higher in males compared with their female counterparts. ... -
Mechanical ventilation weaning protocols in critically ill adults and children
(2020-03-24)What is this? Some patients with COVID-19 will develop respiratory failure and need help with their breathing. This might be provided by mechanical ventilation (MV) in an intensive care unit (ICU). Various methods are ... -
Meningoencephalitis associated with COVID-19: a systematic review
(2020-12-26)With the growing number of COVID-19 cases in recent times. significant set of patients with extra pulmonary symptoms has been reported worldwide. Here we venture out to summarize the clinical profile, investigations, and ... -
Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies and public health implications
(2020-05-08)Serology-based tests have become a key public health element in the COVID-19 pandemic to assess the degree of herd immunity that has been achieved in the population. These tests differ between one another in several ways. ... -
A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19
(2020-08-13)Background: The incidence of venous thromboembolic events (VTE) in patients with COVID-19 is generally high but varies markedly. However, the relationship between anticoagulation and mortality in patients with COVID-19 is ... -
A method to prevent SARS-CoV-2 IgM false positives in gold immunochromatography and enzyme-linked immunosorbent assays
(2020-04-10)[Abstract]. Objective: To investigate the interference factors that lead to false-positive novel coronavirus (SARS-CoV-2) IgM detected using gold immunochromatography assay (GICA) and enzyme-linked immunosorbent assay ... -
Modes of transmission of virus causing COVID-19:implications for IPC precaution recommendations. Scientific Brief, 29 March 2020
(2020-03-29)Modes of transmission of the COVID-19 virus: Respiratory infections can be transmitted through droplets of different sizes: when the droplet particles are >5-10 μm in diameter they are referred to as respiratory droplets, ... -
Molecular detection of SARS-CoV-2 using a reagent-free approach
(2020-05-02)Shortage of reagents and consumables required for the extraction and molecular detection of SARS-CoV-2 RNA in respiratory samples has led many laboratories to investigate alternative approaches for sample preparation. ... -
Molecular Mechanism of Evolution and Human Infection with SARS-CoV-2
(2020-04-10)The outbreak of a novel coronavirus, which was later formally named the severe acute respiratory coronavirus 2 (SARS-CoV-2), has caused a worldwide public health crisis. Previous studies showed that SARS-CoV-2 is highly ...