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FACT- Frankfurt adjusted COVID-19 testing- a novel method enables high-throughput SARS-CoV-2 screening without loss of sensitivity
(2020-05-01)Background: In the pandemic, testing for SARS-CoV-2 by RT-PCR in one of the pillars on which countermeasures are based. Factors limiting the output of laboratories interfere with the effectiveness of public health measures. ... -
False positives in reverse transcription PCR testing for SARS-CoV-2
(2020-05-20)Large-scale testing for SARS-CoV-2 by the reverse transcription polymerase chain reaction is a key part of the response to the COVID-19 pandemic, but little attention has been paid to the potential frequency and impacts ... -
False-Negative results of initial RT-PCR assays for Covid-19: a systematic review
(2020-04-21)Background: Cases with negative reverse transcription-polymerase chain reaction (RT-PCR) results at initial testing for suspicion of SARS-CoV-2 infection, and found to be positive in a subsequent test, are considered as ... -
Full-genome sequences of the first two SARS-CoV-2 viruses from India
(2020)Background & objectives : Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has globally affected 195 countries. In India, suspected cases were screened for SARS-CoV-2 as per the advisory ... -
Gastrointestinal and hepatic manifestations of COVID‐19: A systematic review and meta‐analysis
(2020-11-21)Background and Aim: This review investigates the role of gastrointestinal and hepatic manifestations in COVID‐19, particularly with regard to the prevalence of isolated gastrointestinal (GI) symptoms. Methods: We searched ... -
Gastrointestinal predictors of severe COVID-19: systematic review and meta-analysis
(2020-07-30)Background: COVID-19 pandemic has created a need to identify potential predictors of severe disease. We performed a systematic review and meta-analysis of gastrointestinal predictors of severe COVID-19. Methods: An extensive ... -
Genomic characterization and phylogenetic analysis of SARS‐COV‐2 in Italy
(2020-03-29)This report describes the isolation, molecular characterization, and phylogenetic analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) isolated from three patients ... -
A Genomic Perspective on the Origin and Emergence of SARS-CoV-2
(2020-03-26)The ongoing pandemic of a new human coronavirus, SARS-CoV-2, has generated enormous global concern. We and others in China were involved in the initial genome sequencing of the virus. Herein, we describe what genomic data ... -
Group Testing Performance Evaluation for SARS-CoV-2 Massive Scale Screening and Testing
(2020-05-05)The capacity of current molecular testing convention does not allow high-throughput and community level scans of COVID-19 infections. The diameter in current paradigm of shallow tracing is unlikely to reach the silent ... -
Heating, Ventilation, and Air Conditioning Systems in Public Spaces
(2020-09-29)Heating, ventilation, and air conditioning (HVAC) systems are a common and important part of building operations for both health care and non-health care settings, including schools and workplaces. More robust, published, ... -
High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design
(2020-05-22)Little is known about the quality of polyclonal antibody responses in COVID-19 patients, and how it correlates with disease severity or patients' prior exposure to other pathogens. The whole polyclonal antibody repertoire ... -
Histopathological observations in COVID-19: a systematic review
(2020-08-18)Background: Coronavirus disease-2019 (COVID-19) has caused a great global threat to public health. The World Health Organization (WHO) has declared COVID-19 disease as a pandemic, affecting the human respiratory and other ... -
Household Transmission of SARS-CoV-2
(2020-03-21)[Abstract]. Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an epidemic in China and many other countries. Many infected clusters have been found within familial households, but the data ... -
How best to use limited tests? Improving COVID-19 surveillance in long-term care
(2020-04-22)Background: Long-term care facilities (LTCFs) are particularly vulnerable to nosocomial outbreaks of coronavirus disease 2019 (COVID-19), with high rates of transmission and mortality. Timely epidemiological surveillance ... -
Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins
(2020-03-26)The ongoing outbreak of viral pneumonia in China and across the world is associated with a new coronavirus, SARS-CoV-2. This outbreak has been tentatively associated with a seafood market in Wuhan, China, where the sale ... -
Immune response following infection with SARS‐CoV‐2 and other coronaviruses: A rapid review
(2020-09-23)In this review, we systematically searched and summarized the evidence on the immune response and reinfection rate following SARS‐CoV‐2 infection. We also retrieved studies on SARS‐CoV and MERS‐CoV to assess the long‐term ... -
Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model
(2020-05-01)Background In response to the SARS-CoV2 pandemic, governments have adopted a variety of public health measures. There are variations in how much testing has been done across countries. South Korea, Germany, and Iceland ... -
Inactivation of Severe Acute Respiratory Syndrome Coronavirus 2 by WHO-Recommended Hand Rub Formulations and Alcohols
(2020-07)Infection control instructions call for use of alcohol-based hand rub solutions to inactivate severe acute respiratory syndrome coronavirus 2. We determined the virucidal activity of World Health Organization–recommended ... -
Incidence and Persistence of Viral Shedding in COVID-19 Post-acute Patients With Negativized Pharyngeal Swab: A Systematic Review
(2020-08-28)After the global spread of a severe acute respiratory syndrome caused by a coronavirus (SARS-CoV-2), factors that influence viral diffusion have gained great attention. Human-to-human transmission mainly occurs through ...