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COVID-19: Attacks the 1-Beta Chain of Hemoglobin and Captures the Porphyrin to Inhibit Human Heme Metabolism
(2020-04)The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory infection caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. In this study, conserved ... -
COVID-19: Roche Antibody Test – 14th May
(2020-05-14)What do sensitivity and specificity tell us? Sensitivity tells us the proportion of people who test positive, out of the population who should have tested positive. In this case, a sensitivity of 100% tells us that everybody ... -
Current evidence of SARS-CoV-2 vertical transmission: an integrative review
(2020-09-21)OBJECTIVE: To review the current scientific evidence of vertical transmission related to coronavirus disease 2019 (COVID-19). METHODS: An integrative review was performed by two independent researchers, based on the ... -
Decontamination and Reuse of Filtering Facepiece Respirators
(2020-04)Disposable filtering facepiece respirators (FFRs) are not approved for routine decontamination and reuse as standard of care. However, FFR decontamination and reuse may need to be considered as a crisis capacity strategy ... -
Detectable SARS‐CoV‐2 viral RNA in feces of three children during recovery period of COVID‐19 pneumonia
(2020-03-29)Coronavirus Disease 2019 (COVID‐19) is a newly emerging infectious disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). After its first occurrence in Wuhan of China from ... -
Detection of 2019 Novel Coronavirus (2019-nCoV) by Real-Time RT-PCR
Background: The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak ... -
Detection of SARS-CoV-2 RNA by direct RT-qPCR on nasopharyngeal specimens without extraction of viral RNA
(2020-05-19)To circumvent the limited availability of RNA extraction reagents, we aimed to develop a protocol for direct RT-qPCR to detect SARS-CoV-2 in nasopharyngeal swabs without RNA extraction. Nasopharyngeal specimens positive ... -
Development and Multicenter Performance Evaluation of The First Fully Automated SARS-CoV-2 IgM and IgG Immunoassays
(2020-04-21)BACKGROUND: The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly spread globally. The laboratory diagnosis of SARS-CoV-2 infection has relied on nucleic acid tests. However, there are ... -
Development of Genetic Diagnostic Methods for Novel Coronavirus 2019 (nCoV-2019) in Japan
(2020-02-13)At the end of 2019, pneumonia caused by novel coronavirus 2019 (nCoV) emerged in Wuhan city, China. Many airline travelers moved between Wuhan and Japan at that time, suggesting that Japan is at high risk of invasion by ... -
Diagnostic Testing for Severe Acute Respiratory Syndrome–Related Coronavirus-2: A Narrative Review
(2020-04-13)Diagnostic testing to identify persons infected with severe acute respiratory syndrome–related coronavirus-2 (SARS–CoV-2) infection is central to control the global pandemic of COVID-19 that began in late 2019. In a few ... -
The dilemma of COVID-19 in dental practice concerning the role of saliva in transmission: a brief review of current evidence
(2020-05)From December 12, 2019, a pandemic of acute respiratory syndrome, the novel human coronavirus disease (COVID-19), caused by a novel β-coronavirus (2019-nCoV) began to grow globally by person-to-person transmission. The ... -
Does gender influence clinical expression and disease outcomes in COVID-19? A systematic review and meta-analysis
(2020-08-12)Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) was characterized at the end of 2019, and soon spread around the world, generating a pandemic. It has been suggested that men are more severely affected ... -
Early estimation of the case fatality rate of COVID-19 in mainland China: a data-driven analysis
(2020-02-12)An ongoing outbreak of pneumonia caused by a novel coronavirus [severe acute respiratory syndrome coronavirus (SARS-CoV)-2], named COVID-19, hit a major city of China, Wuhan in December 2019 and subsequently spread to other ... -
Echocardiographic Features of Cardiac Injury Related to COVID-19 and Their Prognostic Value: A Systematic Review
(2020-12-22)[Abstract]. Background: The available information on the echocardiographic features of cardiac injury related to the novel coronavirus disease 2019 (COVID-19) and their prognostic value are scattered in the different ... -
Effect of Heat inactivation on Real-Time Reverse Transcription PCR of the SARS-COV-2 Detection
(2020-05-28)Background: Real-time reverse transcription PCR (rRT-PCR) is commonly used to diagnose SARS-CoV-2 infection. Heat inactivation prior to nucleic acid isolation may allow safe testing, while the effects of heat inactivation ... -
Effects of temperature and humidity on the spread of COVID-19: A systematic review
(2020-09-18)Background: Faced with the global pandemic of COVID-19, declared by World Health Organization (WHO) on March 11th 2020, and the need to better understand the seasonal behavior of the virus, our team conducted this systematic ... -
Efficient Prevalence Estimation and Population Screening for SARS-CoV-2
(2020-05-22)The testing capacity for SARS-CoV-2 using RT-PCR analyses can be substantially increased by using pooling techniques. Here we discuss two important consequences of this. First, prevalence estimation can be done with a very ... -
The Epidemiology and Pathogenesis of Coronavirus Disease (COVID-19) Outbreak
(2020-02-26)Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were ... -
Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020
(2020-03-12)On 5 February 2020, in Yokohama, Japan, a cruise ship hosting 3,711 people underwent a 2-week quarantine after a former passenger was found with COVID-19 post-disembarking. As at 20 February, 634 persons on board tested ... -
Exacerbation of neurological symptoms and COVID-19 severity in patients with preexisting neurological disorders and COVID-19: A systematic review
(2020-11-01)Background: Patients with chronic diseases likely develop severe 2019 coronavirus disease (COVID-19). However, little is known about the effects of COVID-19 on patients with neurological disorders. We conducted a systematic ...