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Effect of remdesivir on patients with COVID-19: A network meta-analysis of randomized control trials
dc.contributor.author | Yokoyama, Yujiro | |
dc.contributor.author | Briasoulis, Alexandros | |
dc.contributor.author | Takagi, Hisato | |
dc.contributor.author | Kuno, Toshiki | |
dc.date.accessioned | 2020-09-03T19:38:16Z | |
dc.date.available | 2020-09-03T19:38:16Z | |
dc.date.issued | 2020-10-15 | |
dc.identifier.uri | https://doi.org/10.1016/j.virusres.2020.198137 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/2170 | |
dc.description.abstract | Several randomized controlled trials (RCTs) were conducted to investigate the effect of remdesivir for patients with COVID-19, but their results were conflicting. Thus, we conducted a network meta-analysis comparing the rate of clinical improvement among patients with COVID-19 who received 5-day course of remdesivir versus 10-day course of remdesivir versus standard care. Our network meta-analysis of 4 randomized controlled trials demonstrated that the rate of clinical improvement was significantly higher in the 5-day remdesivir group and 10-day remdesivir group compared to standard care group (OR [95% confidence interval [CI]] =1.89 [1.40-2.56], P <0.001, OR [95% CI] =1.38 [1.15-1.66], P <0.001, respectively). In addition, the rate of clinical improvement was significantly higher in the 5-day remdesivir group compared to the 10-day remdesivir group (OR [95% confidence interval [CI]] =1.37 [1.01-1.85], P =0.041). Our analysis demonstrated that the use of remdesivir for patients with COVID-19 was associated with the significantly higher clinical improvement rate compared with standard care alone. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Remdesivir | en_US |
dc.subject | Drug Therapy | en_US |
dc.subject | Antiviral Agents | en_US |
dc.subject | Meta-Analysis | en_US |
dc.title | Effect of remdesivir on patients with COVID-19: A network meta-analysis of randomized control trials | en_US |
eihealth.country | Others | en_US |
eihealth.category | Candidate therapeutics RD | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Virus Research | en_US |
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